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TargetTubulin alpha chain /beta chain
LigandBDBM50005480
Substrate/Competitorn/a
Meas. Tech.ChEMBL_51441
IC50 1900±n/a nM
Citation Mu FHamel ELee DJPryor DECushman M Synthesis, anticancer activity, and inhibition of tubulin polymerization by conformationally restricted analogues of lavendustin A. J Med Chem 46:1670-82 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tubulin alpha chain /beta chain
Name:Tubulin alpha chain /beta chain
Synonyms:Tubulin
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of EBI is 51441
Components:This complex has 2 components.
Component 1
Name:Tubulin
Synonyms:Tubulin beta chain
Type:PROTEIN
Mol. Mass.:49932.38
Organism:Bos taurus
Description:ChEMBL_211651
Residue:445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA
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Component 2
Name:Tubulin
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:9422.48
Organism:Bos taurus
Description:EBI_18002
Residue:84
Sequence:
PSPQVSTAVVEPYNSILTTKHLEHSDCFMVDNEAIYDICRRNLDIERPTTRNLNRLMSQI
VSSITASLRFDGALTVDLTDVQTS
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BDBM50005480
n/a
NameBDBM50005480
Synonyms:(-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetramethoxystilbene | (Z)-5-(3,4,5-trimethoxystyryl)-2-methoxyphenol | (combretastatin A-4)2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol | (combretastin A-4)2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol | 2-Methoxy-5-[(Z)-2-(3,4,5-trimethox y-phenyl)-vinyl]-phenol | 2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol | 2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol | 2-methoxy-5-(3,4,5-trimethoxystyryl)phenol | 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenol | 5-(3,4,5-trimethoxystyryl)-2-methoxyphenol | 5-[(S)-2-Hydroxy-2-(3,4,5-trimethoxy-phenyl)-ethyl]-2-methoxy-phenol | CHEMBL67 | Combrestatin A-4 | Combrestatin A4 | Combretastastin A-4 | Combretastatin | Combretastatin-A4 | Combretastin A-4 | Z-Combretastatin A-4 | combretastatin A-4, (CSA4) | combretastin A4
TypeSmall organic molecule
Emp. Form.C18H20O5
Mol. Mass.316.3484
SMILESCOc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
Structure
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