Reaction Details |
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Target | Gonadotropin-releasing hormone receptor |
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Ligand | BDBM50127191 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_71588 (CHEMBL684202) |
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Ki | 1.2±n/a nM |
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Citation | Zhu, YF; Guo, Z; Gross, TD; Gao, Y; Connors, PJ; Struthers, RS; Xie, Q; Tucci, FC; Reinhart, GJ; Wu, D; Saunders, J; Chen, C Design and structure-activity relationships of 2-alkyl-3-aminomethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists. J Med Chem46:1769-72 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Gonadotropin-releasing hormone receptor |
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Name: | Gonadotropin-releasing hormone receptor |
Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) |
Type: | Enzyme |
Mol. Mass.: | 37749.45 |
Organism: | Homo sapiens (Human) |
Description: | P30968 |
Residue: | 328 |
Sequence: | MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL
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BDBM50127191 |
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n/a |
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Name | BDBM50127191 |
Synonyms: | 2-(8-(2-Fluoro-benzyl)-6-(3-methoxy-phenyl)-7-methyl-3-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-5-oxo-5,8-dihydro-imidazo[1,2-a]pyrimidin-2-yl)-2-methyl-propionic acid methyl ester | CHEMBL298982 |
Type | Small organic molecule |
Emp. Form. | C35H38FN5O4 |
Mol. Mass. | 611.7057 |
SMILES | COC(=O)C(C)(C)c1nc2n(Cc3ccccc3F)c(C)c(-c3cccc(OC)c3)c(=O)n2c1CN(C)CCc1ccccn1 |
Structure |
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