| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor alpha |
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| Ligand | BDBM28661 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_153706 |
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| EC50 | 2500±n/a nM |
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| Citation |  Sznaidman, ML; Haffner, CD; Maloney, PR; Fivush, A; Chao, E; Goreham, D; Sierra, ML; LeGrumelec, C; Xu, HE; Montana, VG; Lambert, MH; Willson, TM; Oliver, WR; Sternbach, DD Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity. Bioorg Med Chem Lett13:1517-21 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor alpha |
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| Name: | Peroxisome proliferator-activated receptor alpha |
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| Synonyms: | Nr1c1 | Nuclear receptor subfamily 1 group C member 1 | PPAR-alpha | PPARA_MOUSE | Peroxisome Proliferator-Activated Receptor alpha | Ppar | Ppara |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52343.28 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_572395 |
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| Residue: | 468 |
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| Sequence: | MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSIGEESSGSFGFADYQYLGSC
PGSEGSVITDTLSPASSPSSVSCPVIPASTDESPGSALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDLKDSETADLKSLGKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFV
IHDMETLCMAEKTLVAKMVANGVEDKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDT
FLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY
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| BDBM28661 |
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| n/a |
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| Name | BDBM28661 |
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| Synonyms: | 2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetic acid | CHEMBL38943 | GW 501516 | GW-501516 | GW1516 | GW501516 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18F3NO3S2 |
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| Mol. Mass. | 453.498 |
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| SMILES | Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F |
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| Structure | 
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