| Reaction Details |
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 | Report a problem with these data |
| Target | Geranylgeranyl transferase type-1 subunit beta |
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| Ligand | BDBM50127315 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_71806 |
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| IC50 | 24±n/a nM |
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| Citation |  Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability. Bioorg Med Chem Lett13:1571-4 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Geranylgeranyl transferase type-1 subunit beta |
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| Name: | Geranylgeranyl transferase type-1 subunit beta |
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| Synonyms: | 2.5.1.59 | GGTase-I-beta | Geranylgeranyl transferase type I | Geranylgeranyl transferase type I beta subunit | Geranylgeranyl transferase type I subunit beta | Geranylgeranyl transferase type-1 subunit beta | PGGT1B | PGTB1_HUMAN | Protein farnesyl/geranylgeranyl transferase | Type I protein geranyl-geranyltransferase subunit beta |
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| Type: | n/a |
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| Mol. Mass.: | 42369.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 377 |
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| Sequence: | MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM
LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSG
HIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC
ICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF
SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS
TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQS
WKTKDSKQCSENVHIST
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| BDBM50127315 |
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| n/a |
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| Name | BDBM50127315 |
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| Synonyms: | 6-[(4-Cyano-3-naphthalen-1-yl-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-nicotinonitrile | A-315493 | CHEMBL43631 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H21N5O |
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| Mol. Mass. | 455.5099 |
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| SMILES | Cn1cncc1C(OCc1ccc(cn1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12 |
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| Structure | 
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