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TargetGeranylgeranyl transferase type-1 subunit beta
LigandBDBM50127324
Substrate/Competitorn/a
Meas. Tech.ChEBML_71806
IC50 1400±n/a nM
Citation Tong, YLin, NHWang, LHasvold, LWang, WLeonard, NLi, TLi, QCohen, JGu, WZZhang, HStoll, VBauch, JMarsh, KRosenberg, SHSham, HL Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability. Bioorg Med Chem Lett13:1571-4 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Geranylgeranyl transferase type-1 subunit beta
Name:Geranylgeranyl transferase type-1 subunit beta
Synonyms:2.5.1.59 | GGTase-I-beta | Geranylgeranyl transferase type I | Geranylgeranyl transferase type I beta subunit | Geranylgeranyl transferase type I subunit beta | Geranylgeranyl transferase type-1 subunit beta | PGGT1B | PGTB1_HUMAN | Protein farnesyl/geranylgeranyl transferase | Type I protein geranyl-geranyltransferase subunit beta
Type:n/a
Mol. Mass.:42369.84
Organism:Homo sapiens (Human)
Description:n/a
Residue:377
Sequence:
MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM
LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSG
HIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC
ICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF
SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS
TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQS
WKTKDSKQCSENVHIST
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  Blast E-value cutoff:
BDBM50127324
n/a
NameBDBM50127324
Synonyms:5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-6-(3,5-dichloro-phenyl)-pyridine-2-carbonitrile | CHEMBL41268
TypeSmall organic molecule
Emp. Form.C25H17Cl2N5O
Mol. Mass.474.341
SMILESCn1cncc1C(OCc1ccc(nc1-c1cc(Cl)cc(Cl)c1)C#N)c1ccc(cc1)C#N
Structure
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