| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Interstitial collagenase |
|---|
| Ligand | BDBM50127451 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_106136 (CHEMBL718683) |
|---|
| Ki | >4949.0±n/a nM |
|---|
| Citation |  Cherney, RJ; Duan, JJ; Voss, ME; Chen, L; Wang, L; Meyer, DT; Wasserman, ZR; Hardman, KD; Liu, RQ; Covington, MB; Qian, M; Mandlekar, S; Christ, DD; Trzaskos, JM; Newton, RC; Magolda, RL; Wexler, RR; Decicco, CP Design, synthesis, and evaluation of benzothiadiazepine hydroxamates as selective tumor necrosis factor-alpha converting enzyme inhibitors. J Med Chem46:1811-23 (2003) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Interstitial collagenase |
|---|
| Name: | Interstitial collagenase |
|---|
| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54010.26 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P03956 |
|---|
| Residue: | 469 |
|---|
| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
|
|
|
|---|
| BDBM50127451 |
|---|
| n/a |
|---|
| Name | BDBM50127451 |
|---|
| Synonyms: | CHEMBL53643 | N-Hydroxy-2-[7-(4-methoxy-phenoxy)-1,1-dioxo-1,3,4,5-tetrahydro-1lambda*6*-benzo[f][1,2,5]thiadiazepin-2-yl]-propionamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H21N3O6S |
|---|
| Mol. Mass. | 407.441 |
|---|
| SMILES | COc1ccc(Oc2ccc3c(NCCN([C@H](C)C(=O)NO)S3(=O)=O)c2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
