| Reaction Details |
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 | Report a problem with these data |
| Target | Plasminogen activator inhibitor 1 |
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| Ligand | BDBM50127726 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_155613 |
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| IC50 | 240±n/a nM |
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| Citation |  De Nanteuil, G; Lila-Ambroise, C; Rupin, A; Vallez, MO; Verbeuren, TJ New fibrinolytic agents: benzothiophene derivatives as inhibitors of the t-PA-PAI-1 complex formation. Bioorg Med Chem Lett13:1705-8 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasminogen activator inhibitor 1 |
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| Name: | Plasminogen activator inhibitor 1 |
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| Synonyms: | Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 45064.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05121 |
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| Residue: | 402 |
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| Sequence: | MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
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| BDBM50127726 |
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| n/a |
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| Name | BDBM50127726 |
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| Synonyms: | (E)-3-[5,6-Bis-(biphenyl-4-ylmethoxy)-3-(3-fluoro-phenoxy)-benzo[b]thiophen-2-yl]-2-pyridin-4-yl-acrylic acid | CHEMBL43826 |
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| Type | Small organic molecule |
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| Emp. Form. | C48H34FNO5S |
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| Mol. Mass. | 755.851 |
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| SMILES | OC(=O)C(=C\c1sc2cc(OCc3ccc(cc3)-c3ccccc3)c(OCc3ccc(cc3)-c3ccccc3)cc2c1Oc1cccc(F)c1)\c1ccncc1 |
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| Structure | 
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