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TargetPlasminogen activator inhibitor 1
LigandBDBM50127727
Substrate/Competitorn/a
Meas. Tech.ChEBML_155613
IC50 480±n/a nM
Citation De Nanteuil, GLila-Ambroise, CRupin, AVallez, MOVerbeuren, TJ New fibrinolytic agents: benzothiophene derivatives as inhibitors of the t-PA-PAI-1 complex formation. Bioorg Med Chem Lett13:1705-8 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Plasminogen activator inhibitor 1
Name:Plasminogen activator inhibitor 1
Synonyms:Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1
Type:Enzyme
Mol. Mass.:45064.00
Organism:Homo sapiens (Human)
Description:P05121
Residue:402
Sequence:
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
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  Blast E-value cutoff:
BDBM50127727
n/a
NameBDBM50127727
Synonyms:(E)-3-[5,6-Bis-(biphenyl-4-ylmethoxy)-3-(4-chloro-3-methyl-phenoxy)-benzo[b]thiophen-2-yl]-2-pyridin-4-yl-acrylic acid | CHEMBL296520
TypeSmall organic molecule
Emp. Form.C49H36ClNO5S
Mol. Mass.786.332
SMILESCc1cc(Oc2c(\C=C(\C(O)=O)c3ccncc3)sc3cc(OCc4ccc(cc4)-c4ccccc4)c(OCc4ccc(cc4)-c4ccccc4)cc23)ccc1Cl
Structure
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