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TargetPlasminogen activator inhibitor-1
LigandBDBM50127743
Substrate/Competitorn/a
Meas. Tech.ChEBML_155613
IC50 130±n/a nM
Citation De Nanteuil GLila-Ambroise CRupin AVallez MOVerbeuren TJ New fibrinolytic agents: benzothiophene derivatives as inhibitors of the t-PA-PAI-1 complex formation. Bioorg Med Chem Lett 13:1705-8 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Plasminogen activator inhibitor-1
Name:Plasminogen activator inhibitor-1
Synonyms:Endothelial plasminogen activator inhibitor | PAI | PAI-1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator-1 (PAI-1)
Type:Enzyme
Mol. Mass.:45064.00
Organism:Homo sapiens (Human)
Description:P05121
Residue:402
Sequence:
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
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  Blast E-value cutoff:
BDBM50127743
n/a
NameBDBM50127743
Synonyms:(E)-3-[5,6-Bis-(biphenyl-4-ylmethoxy)-3-(4-chloro-phenoxy)-benzo[b]thiophen-2-yl]-2-pyridin-4-yl-acrylic acid | CHEMBL45498
TypeSmall organic molecule
Emp. Form.C48H34ClNO5S
Mol. Mass.772.305
SMILESOC(=O)C(=C\c1sc2cc(OCc3ccc(cc3)-c3ccccc3)c(OCc3ccc(cc3)-c3ccccc3)cc2c1Oc1ccc(Cl)cc1)\c1ccncc1
Structure
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