Reaction Details |
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Target | ATP-sensitive inward rectifier potassium channel 11 |
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Ligand | BDBM50127767 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_92724 |
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EC50 | 317±n/a nM |
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Citation | Turner, SC; Carroll, WA; White, TK; Brune, ME; Buckner, SA; Gopalakrishnan, M; Fabiyi, A; Coghlan, MJ; Scott, VE; Castle, NA; Daza, AV; Milicic, I; Sullivan, JP Structure-activity relationship of a novel class of naphthyl amide KATP channel openers. Bioorg Med Chem Lett13:1741-4 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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ATP-sensitive inward rectifier potassium channel 11 |
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Name: | ATP-sensitive inward rectifier potassium channel 11 |
Synonyms: | ATP-sensitive inward rectifier potassium channel 11 | IKATP | Inward rectifier K(+) channel Kir6.2 | KCJ11_HUMAN | KCNJ11 | Potassium channel, inwardly rectifying subfamily J member 11 | Potassium channel, inwardly rectifying, subfamily J, member 11 | Sulfonylurea receptor 1, Kir6.2 | Sulfonylurea receptor 2, Kir6.2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 43549.41 |
Organism: | Homo sapiens (Human) |
Description: | Potassium channel (ATP modulatory) 0 0::Q14654 |
Residue: | 390 |
Sequence: | MLSRKGIIPEEYVLTRLAEDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVF
TTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSA
FLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAET
LIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPM
ENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQA
RTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDHSLLEALT
LASARGPLRKRSVPMAKAKPKFSISPDSLS
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BDBM50127767 |
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n/a |
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Name | BDBM50127767 |
Synonyms: | CHEMBL301591 | Quinoxaline-2-carboxylic acid [2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-amide |
Type | Small organic molecule |
Emp. Form. | C22H13F6N3O2 |
Mol. Mass. | 465.3479 |
SMILES | OC(c1ccc2ccccc2c1NC(=O)c1cnc2ccccc2n1)(C(F)(F)F)C(F)(F)F |
Structure |
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