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TargetATP-sensitive inward rectifier potassium channel 11
LigandBDBM50127767
Substrate/Competitorn/a
Meas. Tech.ChEBML_92724
EC50 317±n/a nM
Citation Turner, SCCarroll, WAWhite, TKBrune, MEBuckner, SAGopalakrishnan, MFabiyi, ACoghlan, MJScott, VECastle, NADaza, AVMilicic, ISullivan, JP Structure-activity relationship of a novel class of naphthyl amide KATP channel openers. Bioorg Med Chem Lett13:1741-4 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
ATP-sensitive inward rectifier potassium channel 11
Name:ATP-sensitive inward rectifier potassium channel 11
Synonyms:ATP-sensitive inward rectifier potassium channel 11 | IKATP | Inward rectifier K(+) channel Kir6.2 | KCJ11_HUMAN | KCNJ11 | Potassium channel, inwardly rectifying subfamily J member 11 | Potassium channel, inwardly rectifying, subfamily J, member 11 | Sulfonylurea receptor 1, Kir6.2 | Sulfonylurea receptor 2, Kir6.2
Type:Enzyme Catalytic Domain
Mol. Mass.:43549.41
Organism:Homo sapiens (Human)
Description:Potassium channel (ATP modulatory) 0 0::Q14654
Residue:390
Sequence:
MLSRKGIIPEEYVLTRLAEDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVF
TTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSA
FLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAET
LIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPM
ENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQA
RTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDHSLLEALT
LASARGPLRKRSVPMAKAKPKFSISPDSLS
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  Blast E-value cutoff:
BDBM50127767
n/a
NameBDBM50127767
Synonyms:CHEMBL301591 | Quinoxaline-2-carboxylic acid [2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-amide
TypeSmall organic molecule
Emp. Form.C22H13F6N3O2
Mol. Mass.465.3479
SMILESOC(c1ccc2ccccc2c1NC(=O)c1cnc2ccccc2n1)(C(F)(F)F)C(F)(F)F
Structure
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