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TargetGag-Pol polyprotein [489-587]
LigandBDBM50127977
Substrate/Competitorn/a
Meas. Tech.ChEMBL_159453 (CHEMBL766798)
IC50 0.110000±n/a nM
Citation Lu, ZRaghavan, SBohn, JCharest, MStahlhut, MWRutkowski, CASimcoe, ALOlsen, DBSchleif, WACarella, AGabryelski, LJin, LLin, JHEmini, EChapman, KTata, JR Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus. Bioorg Med Chem Lett13:1821-4 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Gag-Pol polyprotein [489-587]
Name:Gag-Pol polyprotein [489-587]
Synonyms:Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10781.16
Organism:Human immunodeficiency virus type 1
Description:P04585[489-587]
Residue:99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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  Blast E-value cutoff:
BDBM50127977
n/a
NameBDBM50127977
Synonyms:(R)-3-[(2S,4R)-2-Hydroxy-4-((3S,4S)-3-hydroxy-chroman-4-ylcarbamoyl)-5-phenyl-pentanoyl]-5,5-dimethyl-thiazolidine-4-carboxylic acid (3,5-dimethyl-isothiazol-4-ylmethyl)-amide | CHEMBL300754
TypeSmall organic molecule
Emp. Form.C33H40N4O6S2
Mol. Mass.652.824
SMILESCc1nsc(C)c1CNC(=O)[C@H]1N(CSC1(C)C)C(=O)[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H]1[C@H](O)COc2ccccc12
Structure
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