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TargetGag-Pol polyprotein [489-587]
LigandBDBM50127973
Substrate/Competitorn/a
Meas. Tech.ChEMBL_159453 (CHEMBL766798)
IC50 0.720000±n/a nM
Citation Lu, ZRaghavan, SBohn, JCharest, MStahlhut, MWRutkowski, CASimcoe, ALOlsen, DBSchleif, WACarella, AGabryelski, LJin, LLin, JHEmini, EChapman, KTata, JR Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus. Bioorg Med Chem Lett13:1821-4 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Gag-Pol polyprotein [489-587]
Name:Gag-Pol polyprotein [489-587]
Synonyms:Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10781.16
Organism:Human immunodeficiency virus type 1
Description:P04585[489-587]
Residue:99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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  Blast E-value cutoff:
BDBM50127973
n/a
NameBDBM50127973
Synonyms:(R)-3-[(2S,4R)-2-Hydroxy-4-((3S,4S)-3-hydroxy-chroman-4-ylcarbamoyl)-5-phenyl-pentanoyl]-5,5-dimethyl-thiazolidine-4-carboxylic acid (2,4-dimethyl-pyridin-3-ylmethyl)-amide | CHEMBL299884
TypeSmall organic molecule
Emp. Form.C35H42N4O6S
Mol. Mass.646.796
SMILESCc1ccnc(C)c1CNC(=O)[C@H]1N(CSC1(C)C)C(=O)[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H]1[C@H](O)COc2ccccc12
Structure
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