Ki Summary

Reaction Details

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Target

Cholesteryl ester transfer protein

Ligand

BDBM50128131

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_216901 (CHEMBL813013)

IC50

73±n/a nM

Citation

Reinhard, EJ; Wang, JL; Durley, RC; Fobian, YM; Grapperhaus, ML; Hickory, BS; Massa, MA; Norton, MB; Promo, MA; Tollefson, MB; Vernier, WF; Connolly, DT; Witherbee, BJ; Melton, MA; Regina, KJ; Smith, ME; Sikorski, JA Discovery of a simple picomolar inhibitor of cholesteryl ester transfer protein. J Med Chem46:2152-68 (2003) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cholesteryl ester transfer protein

Name:

Cholesteryl ester transfer protein

Synonyms:

CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I

Type:

Enzyme

Mol. Mass.:

54751.53

Organism:

Homo sapiens (Human)

Description:

P11597

Residue:

493

Sequence:

MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS

BDBM50128131

n/a

Name

BDBM50128131

Synonyms:

(R)-3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(4-chloro-3-ethylphenoxy)phenyl)amino)-1,1,1-trifluoropropan-2-ol | (R)-3-((3-(4-chloro-3-ethylphenoxy)phenyl)(3-(1,1,2,2-tetrafluoroethoxy)benzyl)amino)-1,1,1-trifluoropropan-2-ol | 3-{[3-(4-Chloro-3-ethyl-phenoxy)-phenyl]-[3-(1,1,2,2-tetrafluoro-ethoxy)-benzyl]-amino}-1,1,1-trifluoro-propan-2-ol | CHEMBL67129 | SC-795

Type

Small organic molecule

Emp. Form.

C26H23ClF7NO3

Mol. Mass.

565.908

SMILES

CCc1cc(Oc2cccc(c2)N(C[C@@H](O)C(F)(F)F)Cc2cccc(OC(F)(F)C(F)F)c2)ccc1Cl

Structure