| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glutamate carboxypeptidase 2 |
|---|
| Ligand | BDBM50129197 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_71704 |
|---|
| IC50 | 43000±n/a nM |
|---|
| Citation |  Stoermer, D; Liu, Q; Hall, MR; Flanary, JM; Thomas, AG; Rojas, C; Slusher, BS; Tsukamoto, T Synthesis and biological evaluation of hydroxamate-Based inhibitors of glutamate carboxypeptidase II. Bioorg Med Chem Lett13:2097-100 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glutamate carboxypeptidase 2 |
|---|
| Name: | Glutamate carboxypeptidase 2 |
|---|
| Synonyms: | FGCP | FOLH | FOLH1 | FOLH1_HUMAN | Folate hydrolase 1 | Folylpoly-gamma-glutamate carboxypeptidase | Glutamate carboxypeptidase 2 | Glutamate carboxypeptidase II | Membrane glutamate carboxypeptidase | N-acetylated-alpha-linked acidic dipeptidase I | NAALAD1 | NAALADase I | PSM | PSMA | Prostate-specific membrane antigen | Pteroylpoly-gamma-glutamate carboxypeptidase | mGCP |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 84333.66 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1497035 |
|---|
| Residue: | 750 |
|---|
| Sequence: | MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEATNITPKHNMKA
FLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYP
NKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYA
RTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVK
SYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYY
DAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIG
TLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFAS
WDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKE
LKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKN
WETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDY
AVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIV
LRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVD
PSKAWGEVKRQIYVAAFTVQAAAETLSEVA
|
|
|
|---|
| BDBM50129197 |
|---|
| n/a |
|---|
| Name | BDBM50129197 |
|---|
| Synonyms: | 4-(Hydroxyamino)-4-oxobutanoic acid | CHEMBL51979 | N-Hydroxy-succinamic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C4H7NO4 |
|---|
| Mol. Mass. | 133.1027 |
|---|
| SMILES | ONC(=O)CCC(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
