| Reaction Details |
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 | Report a problem with these data |
| Target | Retinoic acid receptor gamma |
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| Ligand | BDBM28681 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_196008 (CHEMBL797872) |
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| Ki | 10000±n/a nM |
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| Citation |  Michellys, PY; Ardecky, RJ; Chen, JH; Crombie, DL; Etgen, GJ; Faul, MM; Faulkner, AL; Grese, TA; Heyman, RA; Karanewsky, DS; Klausing, K; Leibowitz, MD; Liu, S; Mais, DA; Mapes, CM; Marschke, KB; Reifel-Miller, A; Ogilvie, KM; Rungta, D; Thompson, AW; Tyhonas, JS; Boehm, MF Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. J Med Chem46:2683-96 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinoic acid receptor gamma |
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| Name: | Retinoic acid receptor gamma |
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| Synonyms: | NR1B3 | Nuclear receptor subfamily 1 group B member 3 | RAR-gamma | RARG | RARG_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoic acid receptor gamma | Retinoid receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50345.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1458016 |
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| Residue: | 454 |
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| Sequence: | MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMAS
LSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQK
NMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSY
ELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIK
IVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMH
NAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEA
LRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPE
MFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
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| BDBM28681 |
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| n/a |
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| Name | BDBM28681 |
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| Synonyms: | 5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)methyl]-1,3-thiazolidine-2,4-dione | Avandia | BRL 49653 | Brl-49653 | CHEMBL121 | ROSIGLITAZONE MALEATE | [3H]rosiglitazone | cid_5281055 | rosiglitazone |
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| Type | radiolabeled ligand |
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| Emp. Form. | C18H19N3O3S |
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| Mol. Mass. | 357.427 |
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| SMILES | CN(CCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1ccccn1 |
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| Structure | 
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