Reaction Details |
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Target | Peroxisome proliferator-activated receptor gamma/Retinoic acid receptor RXR-alpha |
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Ligand | BDBM50129722 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_44334 (CHEMBL651610) |
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EC50 | 9±n/a nM |
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Citation | Michellys, PY; Ardecky, RJ; Chen, JH; Crombie, DL; Etgen, GJ; Faul, MM; Faulkner, AL; Grese, TA; Heyman, RA; Karanewsky, DS; Klausing, K; Leibowitz, MD; Liu, S; Mais, DA; Mapes, CM; Marschke, KB; Reifel-Miller, A; Ogilvie, KM; Rungta, D; Thompson, AW; Tyhonas, JS; Boehm, MF Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. J Med Chem46:2683-96 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Peroxisome proliferator-activated receptor gamma/Retinoic acid receptor RXR-alpha |
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Name: | Peroxisome proliferator-activated receptor gamma/Retinoic acid receptor RXR-alpha |
Synonyms: | Peroxisome Proliferator-Activated Receptor gamma/Retinoid X receptor alpha | RXR alpha/PPAR gamma |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 43803 |
Components: | This complex has 3 components. |
Component 1 |
Name: | Peroxisome proliferator-activated receptor gamma |
Synonyms: | NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2 |
Type: | Nuclear Receptor |
Mol. Mass.: | 57613.46 |
Organism: | Homo sapiens (Human) |
Description: | P37231 |
Residue: | 505 |
Sequence: | MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL
LQVIKKTETDMSLHPLLQEIYKDLY
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Component 2 |
Name: | Retinoic acid receptor RXR-alpha |
Synonyms: | NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor |
Type: | PROTEIN |
Mol. Mass.: | 50820.38 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1456363 |
Residue: | 462 |
Sequence: | MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
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BDBM50129722 |
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n/a |
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Name | BDBM50129722 |
Synonyms: | 7-[3,5-Bis-(1,1-dimethyl-propyl)-2-ethoxy-phenyl]-3-methyl-octa-2,4,6-trienoic acid | CHEMBL315986 |
Type | Small organic molecule |
Emp. Form. | C27H40O3 |
Mol. Mass. | 412.6047 |
SMILES | CCOc1c(cc(cc1C(C)(C)CC)C(C)(C)CC)C(\C)=C/C=C/C(/C)=C/C(O)=O |
Structure |
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