Reaction Details | |||
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Target | Dipeptidyl peptidase 4 | ||
Ligand | BDBM50129884 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_53208 (CHEMBL664029) | ||
IC50 | 5±n/a nM | ||
Citation | Villhauer, EB; Brinkman, JA; Naderi, GB; Burkey, BF; Dunning, BE; Prasad, K; Mangold, BL; Russell, ME; Hughes, TE 1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties. J Med Chem46:2774-89 (2003) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Dipeptidyl peptidase 4 | |||
Name: | Dipeptidyl peptidase 4 | ||
Synonyms: | ADABP | ADCP2 | Adenosine deaminase complexing protein 2 | CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPP4_HUMAN | DPPIV | Dipeptidyl peptidase 4 (DDP-IV) | Dipeptidyl peptidase 4 (DPP IV) | Dipeptidyl peptidase 4 (DPP-4) | Dipeptidyl peptidase 4 (DPP4) | Dipeptidyl peptidase 4 (DPPIV) | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV (DDP-4) | Dipeptidyl peptidase IV (DDP-IV) | Dipeptidyl peptidase IV (DPP IV) | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | Dipeptidyl peptidase-IV (DPP-4) | Dipeptidyl peptidase-IV (DPP-IV) | T-cell activation antigen CD26 | TP103 | ||
Type: | Enzyme | ||
Mol. Mass.: | 88271.01 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P27487 | ||
Residue: | 766 | ||
Sequence: |
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BDBM50129884 | |||
n/a | |||
Name | BDBM50129884 | ||
Synonyms: | 6-{4-[2-(2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-cyclohexylamino}-nicotinonitrile | CHEMBL94101 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H24N6O | ||
Mol. Mass. | 352.4335 | ||
SMILES | O=C(CNC1CC[C@@H](CC1)Nc1ccc(cn1)C#N)N1CCC[C@H]1C#N |wD:23.26,7.10,(9.43,3.59,;9.76,2.08,;8.61,1.04,;7.14,1.51,;6,.47,;6,-1.07,;4.67,-1.83,;3.34,-1.07,;3.34,.47,;4.67,1.25,;2.01,-1.83,;1.99,-3.37,;.66,-4.13,;.65,-5.67,;1.98,-6.45,;3.32,-5.68,;3.32,-4.14,;1.98,-7.99,;1.97,-9.53,;11.23,1.6,;11.71,.13,;13.25,.13,;13.73,1.6,;12.48,2.51,;13.24,3.85,;14,5.2,)| | ||
Structure |