Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMatrix Metalloproteinase-8 (MMP-8)
LigandBDBM50130108
Substrate/Competitorn/a
Meas. Tech.ChEBML_105213
Ki 9±n/a nM
Citation Robinson LAWilson DMDelaet NGBradley EKDankwardt SMCampbell JAMartin RLVan Wart HEWalker KASullivan RW Novel inhibitors of procollagen C-proteinase. Part 2: glutamic acid hydroxamates. Bioorg Med Chem Lett 13:2381-4 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Matrix Metalloproteinase-8 (MMP-8)
Name:Collagenase
Synonyms:Collagenase 2 | MMP-8 | MMP8 | Matrix metalloproteinase-8 | Neutrophil collagenase | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:Enzyme
Mol. Mass.:53413.48
Organism:Homo sapiens (Human)
Description:n/a
Residue:467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50130108
n/a
NameBDBM50130108
Synonyms:(R)-5-(4-Acetyl-piperazin-1-yl)-2-[benzo[1,3]dioxol-5-ylmethyl-(4-methoxy-benzenesulfonyl)-amino]-5-oxo-pentanoic acid hydroxyamide | CHEMBL432532
TypeSmall organic molecule
Emp. Form.C26H32N4O9S
Mol. Mass.576.619
SMILESCOc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@H](CCC(=O)N1CCN(CC1)C(C)=O)C(=O)NO
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: