| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent serotonin transporter |
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| Ligand | BDBM50130157 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_201993 |
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| Ki | 0.510000±n/a nM |
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| Citation |  Takeuchi, K; Kohn, TJ; Honigschmidt, NA; Rocco, VP; Spinazze, PG; Koch, DJ; Atkinson, ST; Hertel, LW; Nelson, DL; Wainscott, DB; Ahmad, LJ; Shaw, J; Threlkeld, PG; Wong, DT Advances Toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT(1A) receptor antagonism/SSRI activities. Part 2. Bioorg Med Chem Lett13:2393-7 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent serotonin transporter |
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| Name: | Sodium-dependent serotonin transporter |
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| Synonyms: | 5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 70168.43 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P31652 |
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| Residue: | 630 |
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| Sequence: | METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEAS
HSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTII
AWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIH
QSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGA
TLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLT
LTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLIST
PGTLKERIIKSITPETPTEIPCGDIRMNAV
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|
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| BDBM50130157 |
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| n/a |
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| Name | BDBM50130157 |
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| Synonyms: | (S)-1-((4S,6R)-4-Benzo[b]thiophen-2-yl-2-methyl-piperidin-1-yl)-3-(1H-indol-4-yloxy)-propan-2-ol | (S)-1-(1H-indol-4-yloxy)-3-((2S,4R)-4-(benzo[b]thiophen-2-yl)-2-methylpiperidin-1-yl)propan-2-ol | CHEMBL311701 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28N2O2S |
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| Mol. Mass. | 420.567 |
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| SMILES | C[C@H]1C[C@@H](CCN1C[C@H](O)COc1cccc2[nH]ccc12)c1cc2ccccc2s1 |
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| Structure | 
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