| Reaction Details |
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 | Report a problem with these data |
| Target | NF-kappa-B essential modulator |
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| Ligand | BDBM50130248 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_84013 |
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| EC50 | 5000±n/a nM |
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| Citation |  Castro, AC; Dang, LC; Soucy, F; Grenier, L; Mazdiyasni, H; Hottelet, M; Parent, L; Pien, C; Palombella, V; Adams, J Novel IKK inhibitors: beta-carbolines. Bioorg Med Chem Lett13:2419-22 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| NF-kappa-B essential modulator |
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| Name: | NF-kappa-B essential modulator |
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| Synonyms: | FIP3 | IKBKG | Inhibitor of NF-kappa-B kinase (IKK) | NEMO | NEMO_HUMAN | NF-kappa-B essential modulator |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48190.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_84013 |
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| Residue: | 419 |
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| Sequence: | MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE
LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ
ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQ
ARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQE
YDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPV
LKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH
VEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE
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|
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| BDBM50130248 |
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| n/a |
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| Name | BDBM50130248 |
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| Synonyms: | CHEMBL79004 | N-(6-Chloro-9H-beta-carbolin-8-yl)-nicotinamide | PS-1145 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H11ClN4O |
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| Mol. Mass. | 322.748 |
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| SMILES | Clc1cc(NC(=O)c2cccnc2)c2[nH]c3cnccc3c2c1 |
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| Structure | 
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