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TargetC-X-C chemokine receptor type 2
LigandBDBM50221044
Substrate/Competitorn/a
Meas. Tech.ChEMBL_44674 (CHEMBL656547)
IC50<28±n/a nM
Citation Baxter, ABennion, CBent, JBoden, KBrough, SCooper, AKinchin, EKindon, NMcInally, TMortimore, MRoberts, BUnitt, J Hit-to-lead studies: the discovery of potent, orally bioavailable triazolethiol CXCR2 receptor antagonists. Bioorg Med Chem Lett13:2625-8 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
C-X-C chemokine receptor type 2
Name:C-X-C chemokine receptor type 2
Synonyms:C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:Protein
Mol. Mass.:40767.88
Organism:Homo sapiens (Human)
Description:P25025
Residue:360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFL
LSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCK
VVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPV
LLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK
AHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATE
ILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
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BDBM50221044
n/a
NameBDBM50221044
Synonyms:CHEMBL309253
TypeSmall organic molecule
Emp. Form.C15H11Cl2N3S
Mol. Mass.336.239
SMILESSc1nc(nn1Cc1cccc(Cl)c1)-c1ccccc1Cl
Structure
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