Reaction Details |
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Target | Receptor-type tyrosine-protein phosphatase alpha |
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Ligand | BDBM50131551 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_207134 (CHEMBL805118) |
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Ki | 860.0±n/a nM |
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Citation | Liu, G; Xin, Z; Liang, H; Abad-Zapatero, C; Hajduk, PJ; Janowick, DA; Szczepankiewicz, BG; Pei, Z; Hutchins, CW; Ballaron, SJ; Stashko, MA; Lubben, TH; Berg, CE; Rondinone, CM; Trevillyan, JM; Jirousek, MR Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands. J Med Chem46:3437-40 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Receptor-type tyrosine-protein phosphatase alpha |
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Name: | Receptor-type tyrosine-protein phosphatase alpha |
Synonyms: | PTPA | PTPRA | PTPRA_HUMAN | PTPRL2 | Protein-tyrosine phosphatase alpha |
Type: | Enzyme |
Mol. Mass.: | 90719.02 |
Organism: | Homo sapiens (Human) |
Description: | P18433 |
Residue: | 802 |
Sequence: | MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVKEEAKTSNPTSSLTSLS
VAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITISPNGTWLPDNQFTDARTEP
WEGNSSTAATTPETFPPSGNSDSKDRRDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKY
KQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKL
FREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASF
INGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCW
TYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGM
LKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQ
RCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKL
TSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQK
DSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITV
ELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQ
QQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ
YEFCYKVVQEYIDAFSDYANFK
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BDBM50131551 |
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n/a |
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Name | BDBM50131551 |
Synonyms: | 2-carboxy(2-ethyl-4-{2-methylcarboxamido-2-[4-(2-methyloxycarbonylphenoxy)butylcarbamoyl]ethyl}phenyl)carboxamidobenzoic acid | CHEMBL116744 |
Type | Small organic molecule |
Emp. Form. | C34H37N3O10 |
Mol. Mass. | 647.6717 |
SMILES | CCc1cc(CC(NC(C)=O)C(=O)NCCCCOc2ccccc2C(=O)OC)ccc1N(C(=O)C(O)=O)c1ccccc1C(O)=O |
Structure |
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