| Reaction Details |
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 | Report a problem with these data |
| Target | Protein phosphatase 3 catalytic subunit alpha |
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| Ligand | BDBM50131547 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_42593 (CHEMBL655822) |
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| Ki | >3000±n/a nM |
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| Citation |  Liu, G; Xin, Z; Liang, H; Abad-Zapatero, C; Hajduk, PJ; Janowick, DA; Szczepankiewicz, BG; Pei, Z; Hutchins, CW; Ballaron, SJ; Stashko, MA; Lubben, TH; Berg, CE; Rondinone, CM; Trevillyan, JM; Jirousek, MR Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands. J Med Chem46:3437-40 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein phosphatase 3 catalytic subunit alpha |
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| Name: | Protein phosphatase 3 catalytic subunit alpha |
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| Synonyms: | CALNA | CNA | PP2BA_HUMAN | PPP3CA | Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | calcineurin |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 58681.14 |
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| Organism: | Homo sapiens (Human) |
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| Description: | calcineurin 0 HUMAN::Q08209 |
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| Residue: | 521 |
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| Sequence: | MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESV
ALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYV
DRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMD
AFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFG
NEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFP
SLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEK
VTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESV
LTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRIN
ERMPPRRDAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ
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| BDBM50131547 |
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| n/a |
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| Name | BDBM50131547 |
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| Synonyms: | 2-(N-(4-(2-acetamido-3-(4-(5-chloro-3-hydroxy-2-(methoxycarbonyl)phenoxy)butylamino)-3-oxopropyl)-2-ethylphenyl)-1-carboxyformamido)benzoic acid | 2-[4-(2-Acetylamino-3-{4-[(2-carboxy-phenyl)-oxalyl-amino]-3-ethyl-phenyl}-propionylamino)-butoxy]-4-chloro-6-hydroxy-benzoic acid methyl ester | CHEMBL117496 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H36ClN3O11 |
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| Mol. Mass. | 698.116 |
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| SMILES | CCc1cc(CC(NC(C)=O)C(=O)NCCCCOc2cc(Cl)cc(O)c2C(=O)OC)ccc1N(C(=O)C(O)=O)c1ccccc1C(O)=O |
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| Structure | 
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