Reaction Details | |||
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Target | Proto-oncogene tyrosine-protein kinase Src | ||
Ligand | BDBM50132351 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_202612 | ||
IC50 | 0.300000±n/a nM | ||
Citation | Vu, CB; Luke, GP; Kawahata, N; Shakespeare, WC; Wang, Y; Sundaramoorthi, R; Metcalf, CA; Keenan, TP; Pradeepan, S; Corpuz, E; Merry, T; Bohacek, RS; Dalgarno, DC; Narula, SS; van Schravendijk, MR; Ram, MK; Adams, S; Liou, S; Keats, JA; Violette, SM; Guan, W; Weigele, M; Sawyer, TK Bone-targeted pyrido[2,3-d]pyrimidin-7-ones: potent inhibitors of Src tyrosine kinase as novel antiresorptive agents. Bioorg Med Chem Lett13:3071-4 (2003) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Proto-oncogene tyrosine-protein kinase Src | |||
Name: | Proto-oncogene tyrosine-protein kinase Src | ||
Synonyms: | Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src | ||
Type: | Protein | ||
Mol. Mass.: | 59838.60 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P12931 | ||
Residue: | 536 | ||
Sequence: |
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BDBM50132351 | |||
n/a | |||
Name | BDBM50132351 | ||
Synonyms: | ({4-[6-(2,6-Dichloro-phenyl)-8-(3-dimethylamino-propyl)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-phenyl}-hydroxy-phosphinoylmethyl)-phosphonic acid | CHEMBL421024 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H27Cl2N5O6P2 | ||
Mol. Mass. | 626.365 | ||
SMILES | CN(C)CCCn1c2nc(Nc3ccc(cc3)P(O)(=O)CP(O)(O)=O)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(3.9,-7.22,;3.9,-5.68,;2.57,-4.91,;5.23,-4.91,;5.23,-3.37,;6.56,-2.59,;6.56,-1.05,;5.21,-.28,;3.88,-1.05,;2.55,-.29,;1.22,-1.06,;-.11,-.29,;-.11,1.25,;-1.44,2.01,;-2.78,1.23,;-2.77,-.31,;-1.44,-1.07,;-4.12,2,;-4.89,.67,;-3.35,3.34,;-5.45,2.77,;-5.45,4.31,;-6.99,4.32,;-5.86,5.8,;-4.12,5.09,;2.55,1.26,;3.88,2.03,;5.21,1.26,;6.54,2.03,;7.89,1.25,;9.22,2.02,;9.22,3.57,;7.89,4.33,;10.55,4.36,;11.88,3.57,;11.88,2.02,;10.55,1.25,;10.55,-.29,;7.89,-.28,;9.22,-1.05,)| | ||
Structure |