| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK3 |
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| Ligand | BDBM50132428 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_91950 |
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| IC50 | 190±n/a nM |
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| Citation |  Adams, C; Aldous, DJ; Amendola, S; Bamborough, P; Bright, C; Crowe, S; Eastwood, P; Fenton, G; Foster, M; Harrison, TK; King, S; Lai, J; Lawrence, C; Letallec, JP; McCarthy, C; Moorcroft, N; Page, K; Rao, S; Redford, J; Sadiq, S; Smith, K; Souness, JE; Thurairatnam, S; Vine, M; Wyman, B Mapping the kinase domain of Janus Kinase 3. Bioorg Med Chem Lett13:3105-10 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK3 |
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| Name: | Tyrosine-protein kinase JAK3 |
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| Synonyms: | JAK-3 | JAK3 | JAK3_HUMAN | Janus kinase 3 | Janus kinase 3 (JAK3) | Janus kinase 3 JAK3 | L-JAK | Leukocyte janus kinase |
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| Type: | Protein |
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| Mol. Mass.: | 125111.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P52333 |
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| Residue: | 1124 |
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| Sequence: | MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKA
SGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGL
RKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQR
PGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIM
DLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVD
ISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFC
KEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNP
LGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPK
EKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCR
HEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQ
EFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGA
DGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFS
GVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSL
ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCR
YDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRL
VMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESE
AHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL
FTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAP
SPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
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| BDBM50132428 |
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| n/a |
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| Name | BDBM50132428 |
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| Synonyms: | 5-(Hydroxy-thiophen-2-yl-methyl)-3-[1-(1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one | CHEMBL107166 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14N2O2S |
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| Mol. Mass. | 322.381 |
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| SMILES | OC(c1cccs1)c1ccc2NC(=O)\C(=C/c3ccc[nH]3)c2c1 |
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| Structure | 
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