Reaction Details | |||
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Target | Corticotropin-releasing factor receptor 1 | ||
Ligand | BDBM50132935 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_51134 | ||
Ki | 5.1±n/a nM | ||
Citation | Huang, CQ; Wilcoxen, K; McCarthy, JR; Haddach, M; Grigoriadis, D; Chen, C Synthesis of 1-methyl-3-phenylpyrazolo[4,3-b]pyridines via a methylation of 4-phthalimino-3-phenylpyrazoles and optimization toward highly potent corticotropin-releasing factor type-1 antagonists. Bioorg Med Chem Lett13:3371-4 (2003) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Corticotropin-releasing factor receptor 1 | |||
Name: | Corticotropin-releasing factor receptor 1 | ||
Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 50744.31 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P34998 | ||
Residue: | 444 | ||
Sequence: |
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BDBM50132935 | |||
n/a | |||
Name | BDBM50132935 | ||
Synonyms: | CHEMBL112264 | Dibutyl-[1,5-dimethyl-3-(2,4,6-trimethyl-phenyl)-1H-pyrazolo[4,3-b]pyridin-7-yl]-amine | ||
Type | Small organic molecule | ||
Emp. Form. | C25H36N4 | ||
Mol. Mass. | 392.5801 | ||
SMILES | CCCCN(CCCC)c1cc(C)nc2c(nn(C)c12)-c1c(C)cc(C)cc1C |(15.65,1.54,;14.64,.39,;13.12,.69,;12.1,-.45,;10.59,-.15,;10.1,1.31,;11.11,2.47,;10.64,3.93,;11.65,5.09,;9.56,-1.31,;10.04,-2.77,;9.01,-3.91,;9.5,-5.39,;7.51,-3.6,;7.02,-2.14,;5.62,-1.52,;5.78,.02,;7.28,.34,;7.91,1.75,;8.05,-.99,;4.29,-2.3,;4.29,-3.84,;5.63,-4.61,;2.95,-4.61,;1.62,-3.84,;.28,-4.61,;1.62,-2.3,;2.95,-1.53,;2.95,.02,)| | ||
Structure |