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TargetTGF-beta receptor type-1
LigandBDBM50132986
Substrate/Competitorn/a
Meas. Tech.ChEMBL_124315 (CHEMBL732623)
IC50 6.8±n/a nM
Citation Sawyer, JSAnderson, BDBeight, DWCampbell, RMJones, MLHerron, DKLampe, JWMcCowan, JRMcMillen, WTMort, NParsons, SSmith, ECVieth, MWeir, LCYan, LZhang, FYingling, JM Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain. J Med Chem46:3953-6 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
TGF-beta receptor type-1
Name:TGF-beta receptor type-1
Synonyms:ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I
Type:enzyme
Mol. Mass.:55968.24
Organism:Homo sapiens (Human)
Description:P36897
Residue:503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG
LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
ARLTALRIKKTLSQLSQQEGIKM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50132986
n/a
NameBDBM50132986
Synonyms:4-(3-(3-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)quinoline | 4-[3-(3-Trifluoromethyl-phenyl)-1H-pyrazol-4-yl]-quinoline | CHEMBL129678
TypeSmall organic molecule
Emp. Form.C19H12F3N3
Mol. Mass.339.3139
SMILESFC(F)(F)c1cccc(c1)-c1n[nH]cc1-c1ccnc2ccccc12
Structure
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