Ki Summary

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Target

Retinoic acid receptor RXR-beta

Ligand

BDBM50032671

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_197072 (CHEMBL872603)

20±n/a nM

Citation

Michellys, PY; Ardecky, RJ; Chen, JH; D'Arrigo, J; Grese, TA; Karanewsky, DS; Leibowitz, MD; Liu, S; Mais, DA; Mapes, CM; Montrose-Rafizadeh, C; Ogilvie, KM; Reifel-Miller, A; Rungta, D; Thompson, AW; Tyhonas, JS; Boehm, MF Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. J Med Chem46:4087-103 (2003) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Retinoic acid receptor RXR-beta

Name:

Retinoic acid receptor RXR-beta

Synonyms:

Nr2b2 | RXRB_RAT | Rcor-1 | Retinoid X receptor beta | Rxrb

Type:

PROTEIN

Mol. Mass.:

49084.47

Organism:

Rattus norvegicus

Description:

ChEMBL_197072

Residue:

458

Sequence:

GEAGRDGMGDTGRDSRSPDSSSPNPLSQGIPPSSPPGPPHTPSAPPPPMPPPPLGSPFPV
ISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPP
GGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRN
RCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGDGAGGAPEEMPVDRILEAELAVEQKS
DQGVEGPGATGGGGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAG
WNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDK
TELGCLRAIILFNPDAKGLSNPGEVEILREKVYASLETYCKQKYPEQQGRFAKLLLRLPA
LRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA

BDBM50032671

n/a

Name

BDBM50032671

Synonyms:

6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID | 6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-nicotinic acid | CHEMBL288436

Type

Small organic molecule

Emp. Form.

C24H29NO2

Mol. Mass.

363.4926

SMILES

Cc1cc2c(cc1C1(CC1)c1ccc(cn1)C(O)=O)C(C)(C)CCC2(C)C

Structure