| Reaction Details |
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 | Report a problem with these data |
| Target | Retinoic acid receptor RXR-beta |
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| Ligand | BDBM50133118 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_197072 (CHEMBL872603) |
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| Ki | 1.6±n/a nM |
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| Citation |  Michellys, PY; Ardecky, RJ; Chen, JH; D'Arrigo, J; Grese, TA; Karanewsky, DS; Leibowitz, MD; Liu, S; Mais, DA; Mapes, CM; Montrose-Rafizadeh, C; Ogilvie, KM; Reifel-Miller, A; Rungta, D; Thompson, AW; Tyhonas, JS; Boehm, MF Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. J Med Chem46:4087-103 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinoic acid receptor RXR-beta |
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| Name: | Retinoic acid receptor RXR-beta |
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| Synonyms: | Nr2b2 | RXRB_RAT | Rcor-1 | Retinoid X receptor beta | Rxrb |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49084.47 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_197072 |
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| Residue: | 458 |
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| Sequence: | GEAGRDGMGDTGRDSRSPDSSSPNPLSQGIPPSSPPGPPHTPSAPPPPMPPPPLGSPFPV
ISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPP
GGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRN
RCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGDGAGGAPEEMPVDRILEAELAVEQKS
DQGVEGPGATGGGGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAG
WNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDK
TELGCLRAIILFNPDAKGLSNPGEVEILREKVYASLETYCKQKYPEQQGRFAKLLLRLPA
LRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA
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| BDBM50133118 |
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| n/a |
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| Name | BDBM50133118 |
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| Synonyms: | 5-{3-[2-(2,2-Difluoro-ethoxy)-3,5-diisopropyl-phenyl]-thiophen-2-yl}-3-methyl-penta-2,4-dienoic acid | CHEMBL340555 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28F2O3S |
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| Mol. Mass. | 434.539 |
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| SMILES | CC(C)c1cc(C(C)C)c(OCC(F)F)c(c1)-c1ccsc1\C=C\C(\C)=C\C(O)=O |
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| Structure | 
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