| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C alpha type |
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| Ligand | BDBM50133234 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_162571 (CHEMBL768513) |
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| Ki | 4470±n/a nM |
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| Citation |  Sridhar, J; Wei, ZL; Nowak, I; Lewin, NE; Ayres, JA; Pearce, LV; Blumberg, PM; Kozikowski, AP New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity. J Med Chem46:4196-204 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C alpha type |
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| Name: | Protein kinase C alpha type |
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| Synonyms: | KPCA_BOVIN | PKC-alpha | PRKCA | Protein Kinase C, alpha | Protein kinase C alpha |
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| Type: | Enzyme |
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| Mol. Mass.: | 76842.76 |
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| Organism: | Bos taurus (bovine) |
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| Description: | n/a |
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| Residue: | 672 |
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| Sequence: | MADVFPAAEPAAPQDVANRFARKGALRQKNVHEVKNHRFIARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDA
KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPRWDESFTFKLKPSDKDRRL
SEEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNVE
LRQKFEKAKLGPAGNKVISPSEDRRQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA
DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPGKRLGCGPEGERDVREHAFFRRI
DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN
PQFVHPILQSAV
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| BDBM50133234 |
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| n/a |
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| Name | BDBM50133234 |
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| Synonyms: | CHEMBL132714 | N-(5-Hydroxymethyl-2-isopropyl-1-methyl-3-oxo-1,2,3,4,5,6-hexahydro-benzo[e][1,4]diazocin-9-yl)-2-[2-(2-{2-[2-(2-N-(5-Hydroxymethyl-2-isopropyl-1-methyl-3-oxo-1,2,3,4,5,6-hexahydro-benzo[e][1,4]diazocin-9-yl)carbamoylmethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C44H68N6O12 |
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| Mol. Mass. | 873.0437 |
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| SMILES | CC(C)[C@@H]1N(C)c2ccc(NC(=O)COCCOCCOCCOCCOCCOCC(=O)Nc3ccc4C[C@@H](CO)NC(=O)[C@H](C(C)C)N(C)c4c3)cc2C[C@@H](CO)NC1=O |
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| Structure | 
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