Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetProtein Kinase C, alpha
LigandBDBM50133237
Substrate/Competitorn/a
Meas. Tech.ChEMBL_162571
Ki 296±n/a nM
Citation Sridhar JWei ZLNowak ILewin NEAyres JAPearce LVBlumberg PMKozikowski AP New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity. J Med Chem 46:4196-204 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein Kinase C, alpha
Name:Protein kinase C alpha
Synonyms:PKC-alpha | Protein kinase C alpha
Type:Enzyme
Mol. Mass.:76842.76
Organism:Bos taurus (bovine)
Description:n/a
Residue:672
Sequence:
MADVFPAAEPAAPQDVANRFARKGALRQKNVHEVKNHRFIARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDA
KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPRWDESFTFKLKPSDKDRRL
SEEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNVE
LRQKFEKAKLGPAGNKVISPSEDRRQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA
DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPGKRLGCGPEGERDVREHAFFRRI
DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN
PQFVHPILQSAV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50133237
n/a
NameBDBM50133237
Synonyms:CHEMBL133777 | Nonanoic acid 4-((2S,4R)-2-hydroxymethyl-4-isopropyl-5-oxo-pyrrolidin-3-yl)-naphthalen-1-yl ester
TypeSmall organic molecule
Emp. Form.C27H37NO4
Mol. Mass.439.587
SMILESCCCCCCCCC(=O)Oc1ccc(C2[C@@H](CO)NC(=O)[C@@H]2C(C)C)c2ccccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: