Ki Summary

Reaction Details

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Target

Protein kinase C alpha type

Ligand

BDBM50133244

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_162571 (CHEMBL768513)

254±n/a nM

Citation

Sridhar, J; Wei, ZL; Nowak, I; Lewin, NE; Ayres, JA; Pearce, LV; Blumberg, PM; Kozikowski, AP New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity. J Med Chem46:4196-204 (2003) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Protein kinase C alpha type

Name:

Protein kinase C alpha type

Synonyms:

KPCA_BOVIN | PKC-alpha | PRKCA | Protein Kinase C, alpha | Protein kinase C alpha

Type:

Enzyme

Mol. Mass.:

76842.76

Organism:

Bos taurus (bovine)

Description:

n/a

Residue:

672

Sequence:

MADVFPAAEPAAPQDVANRFARKGALRQKNVHEVKNHRFIARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDA
KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPRWDESFTFKLKPSDKDRRL
SEEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNVE
LRQKFEKAKLGPAGNKVISPSEDRRQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA
DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPGKRLGCGPEGERDVREHAFFRRI
DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN
PQFVHPILQSAV

BDBM50133244

n/a

Name

BDBM50133244

Synonyms:

CHEMBL134287 | Hexadecanedioic acid 4-(2-hydroxymethyl-4-isopropyl-5-oxo-pyrrolidin-3-yl)-naphthalen-1-yl ester naphthalen 4-(2-hydroxymethyl-4-isopropyl-5-oxo-pyrrolidin-3-yl)-1-yl ester

Type

Small organic molecule

Emp. Form.

C52H68N2O8

Mol. Mass.

849.1049

SMILES

CC(C)[C@@H]1C([C@@H](CO)NC1=O)c1ccc(OC(=O)CCCCCCCCCCCCCCC(=O)Oc2ccc([C@@H]3[C@@H](CO)NC(=O)[C@@H]3C(C)C)c3ccccc23)c2ccccc12

Structure