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TargetProtein Kinase C, alpha
LigandBDBM50133247
Substrate/Competitorn/a
Meas. Tech.ChEMBL_162571
Ki 208±n/a nM
Citation Sridhar JWei ZLNowak ILewin NEAyres JAPearce LVBlumberg PMKozikowski AP New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity. J Med Chem 46:4196-204 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein Kinase C, alpha
Name:Protein kinase C alpha
Synonyms:PKC-alpha | Protein kinase C alpha
Type:Enzyme
Mol. Mass.:76842.76
Organism:Bos taurus (bovine)
Description:n/a
Residue:672
Sequence:
MADVFPAAEPAAPQDVANRFARKGALRQKNVHEVKNHRFIARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDA
KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPRWDESFTFKLKPSDKDRRL
SEEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNVE
LRQKFEKAKLGPAGNKVISPSEDRRQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA
DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPGKRLGCGPEGERDVREHAFFRRI
DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN
PQFVHPILQSAV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50133247
n/a
NameBDBM50133247
Synonyms:CHEMBL337522 | Decanedioic acid 4-(2-hydroxymethyl-4-isopropyl-5-oxo-pyrrolidin-3-yl)-naphthalen-1-yl ester naphthalen 4-(2-hydroxymethyl-4-isopropyl-5-oxo-pyrrolidin-3-yl)-1-yl ester
TypeSmall organic molecule
Emp. Form.C46H56N2O8
Mol. Mass.764.9454
SMILESCC(C)[C@@H]1C([C@@H](CO)NC1=O)c1ccc(OC(=O)CCCCCCCCC(=O)Oc2ccc([C@@H]3[C@@H](CO)NC(=O)[C@@H]3C(C)C)c3ccccc23)c2ccccc12
Structure
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