Ki Summary

Reaction Details

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Target

Protein kinase C alpha type

Ligand

BDBM50122946

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_162571 (CHEMBL768513)

225±n/a nM

Citation

Sridhar, J; Wei, ZL; Nowak, I; Lewin, NE; Ayres, JA; Pearce, LV; Blumberg, PM; Kozikowski, AP New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity. J Med Chem46:4196-204 (2003) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Protein kinase C alpha type

Name:

Protein kinase C alpha type

Synonyms:

KPCA_BOVIN | PKC-alpha | PRKCA | Protein Kinase C, alpha | Protein kinase C alpha

Type:

Enzyme

Mol. Mass.:

76842.76

Organism:

Bos taurus (bovine)

Description:

n/a

Residue:

672

Sequence:

MADVFPAAEPAAPQDVANRFARKGALRQKNVHEVKNHRFIARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDA
KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPRWDESFTFKLKPSDKDRRL
SEEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNVE
LRQKFEKAKLGPAGNKVISPSEDRRQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA
DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPGKRLGCGPEGERDVREHAFFRRI
DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN
PQFVHPILQSAV

BDBM50122946

n/a

Name

BDBM50122946

Synonyms:

CHEMBL334195 | Hexanoic acid (5-hydroxymethyl-2-isopropyl-1-methyl-3-oxo-1,2,3,4,5,6-hexahydro-benzo[e][1,4]diazocin-8-yl)-amide | Hexanoic acid [(S)-5-hydroxymethyl-2-((S)-isopropyl)-1-methyl-3-oxo-1,2,3,4,5,6-hexahydro-benzo[e][1,4]diazocin-8-yl]-amide

Type

Small organic molecule

Emp. Form.

C21H33N3O3

Mol. Mass.

375.505

SMILES

CCCCCC(=O)Nc1ccc2N(C)[C@@H](C(C)C)C(=O)N[C@H](CO)Cc2c1

Structure