| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-type tyrosine-protein phosphatase alpha |
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| Ligand | BDBM50133279 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_207129 (CHEMBL805113) |
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| Ki | 634000±n/a nM |
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| Citation |  Liu, G; Xin, Z; Pei, Z; Hajduk, PJ; Abad-Zapatero, C; Hutchins, CW; Zhao, H; Lubben, TH; Ballaron, SJ; Haasch, DL; Kaszubska, W; Rondinone, CM; Trevillyan, JM; Jirousek, MR Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor. J Med Chem46:4232-5 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-type tyrosine-protein phosphatase alpha |
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| Name: | Receptor-type tyrosine-protein phosphatase alpha |
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| Synonyms: | PTPA | PTPRA | PTPRA_HUMAN | PTPRL2 | Protein-tyrosine phosphatase alpha |
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| Type: | Enzyme |
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| Mol. Mass.: | 90719.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P18433 |
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| Residue: | 802 |
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| Sequence: | MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVKEEAKTSNPTSSLTSLS
VAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITISPNGTWLPDNQFTDARTEP
WEGNSSTAATTPETFPPSGNSDSKDRRDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKY
KQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKL
FREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASF
INGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCW
TYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGM
LKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQ
RCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKL
TSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQK
DSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITV
ELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQ
QQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ
YEFCYKVVQEYIDAFSDYANFK
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| BDBM50133279 |
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| n/a |
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| Name | BDBM50133279 |
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| Synonyms: | 5-(3-Butyrylamino-phenyl)-isoxazole-3-carboxylic acid | 5-(3-butyramidophenyl)isoxazole-3-carboxylic acid | CHEMBL333158 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H14N2O4 |
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| Mol. Mass. | 274.272 |
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| SMILES | CCCC(=O)Nc1cccc(c1)-c1cc(no1)C(O)=O |
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| Structure | 
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