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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Lanosterol synthase | ||
| Ligand | BDBM50095601 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_148893 (CHEMBL758674) | ||
| IC50 | 22±n/a nM | ||
| Citation |  Hinshaw, JC; Suh, DY; Garnier, P; Buckner, FS; Eastman, RT; Matsuda, SP; Joubert, BM; Coppens, I; Joiner, KA; Merali, S; Nash, TE; Prestwich, GD Oxidosqualene cyclase inhibitors as antimicrobial agents. J Med Chem46:4240-3 (2003) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Lanosterol synthase | |||
| Name: | Lanosterol synthase | ||
| Synonyms: | 2,3-epoxysqualene--lanosterol cyclase | LSS | LSS_HUMAN | OSC | Oxidosqualene--lanosterol cyclase | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 83309.32 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_11231 | ||
| Residue: | 732 | ||
| Sequence: |
| ||
| BDBM50095601 | |||
| n/a | |||
| Name | BDBM50095601 | ||
| Synonyms: | CHEMBL25405 | [4-(1-Aza-bicyclo[2.2.2]oct-3-yloxy)-phenyl]-(4-chloro-phenyl)-methanone | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H20ClNO2 | ||
| Mol. Mass. | 341.831 | ||
| SMILES | Clc1ccc(cc1)C(=O)c1ccc(OC2CN3CCC2CC3)cc1 |THB:13:14:20.21:18.17,(8.94,-7.02,;7.44,-6.62,;7.03,-5.14,;5.55,-4.75,;4.47,-5.85,;4.87,-7.34,;6.36,-7.72,;2.98,-5.45,;1.89,-6.55,;2.57,-3.96,;1.08,-3.58,;.68,-2.09,;1.76,-.99,;1.36,.49,;-.13,.89,;-1.37,.23,;-2.35,1.8,;-4.22,1.75,;-2.98,2.49,;-1.1,2.42,;-.62,3.39,;-1.73,3.01,;3.25,-1.38,;3.65,-2.86,)| | ||
| Structure | 
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