Reaction Details |
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Target | Glycogen phosphorylase, liver form |
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Ligand | BDBM50133438 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_99042 (CHEMBL712595) |
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IC50 | 4±n/a nM |
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Citation | Ogawa, AK; Willoughby, CA; Bergeron, R; Ellsworth, KP; Geissler, WM; Myers, RW; Yao, J; Harris, G; Chapman, KT Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors. Bioorg Med Chem Lett13:3405-8 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Glycogen phosphorylase, liver form |
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Name: | Glycogen phosphorylase, liver form |
Synonyms: | Glycogen Phosphorylase (PYGL) | Glycogen Phosphorylase, liver form | Liver glycogen phosphorylase | PYGL | PYGL_HUMAN |
Type: | Homodimer |
Mol. Mass.: | 97153.98 |
Organism: | Homo sapiens (Human) |
Description: | Dimers associate into a tetramer to form the enzymatically active phosphorylase A. |
Residue: | 847 |
Sequence: | MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTV
RDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDI
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEA
DDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVN
TMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKL
PWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFP
KDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKF
QNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQ
ENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFV
PRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPA
TDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVA
ALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEA
YVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNE
SNKVNGN
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BDBM50133438 |
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n/a |
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Name | BDBM50133438 |
Synonyms: | 4-(2-Chloro-phenyl)-1-(3,4-dimethoxy-benzyl)-6-methyl-1,4-dihydro-pyridine-2,3,5-tricarboxylic acid 5-isopropyl ester | CHEMBL115341 |
Type | Small organic molecule |
Emp. Form. | C27H28ClNO8 |
Mol. Mass. | 529.966 |
SMILES | COc1ccc(CN2C(C)=C(C(C(C(O)=O)=C2C(O)=O)c2ccccc2Cl)C(=O)OC(C)C)cc1OC |c:9,15| |
Structure |
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