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TargetGlycogen phosphorylase, liver form
LigandBDBM50133430
Substrate/Competitorn/a
Meas. Tech.ChEMBL_99042 (CHEMBL712595)
IC50 11±n/a nM
Citation Ogawa, AKWilloughby, CABergeron, REllsworth, KPGeissler, WMMyers, RWYao, JHarris, GChapman, KT Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors. Bioorg Med Chem Lett13:3405-8 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Glycogen phosphorylase, liver form
Name:Glycogen phosphorylase, liver form
Synonyms:Glycogen Phosphorylase (PYGL) | Glycogen Phosphorylase, liver form | Liver glycogen phosphorylase | PYGL | PYGL_HUMAN
Type:Homodimer
Mol. Mass.:97153.98
Organism:Homo sapiens (Human)
Description:Dimers associate into a tetramer to form the enzymatically active phosphorylase A.
Residue:847
Sequence:
MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTV
RDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDI
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEA
DDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVN
TMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKL
PWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFP
KDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKF
QNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQ
ENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFV
PRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPA
TDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVA
ALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEA
YVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNE
SNKVNGN
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  Blast E-value cutoff:
BDBM50133430
n/a
NameBDBM50133430
Synonyms:1-Benzyl-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-2,3,5-tricarboxylic acid 5-isopropyl ester | CHEMBL114731
TypeSmall organic molecule
Emp. Form.C25H24ClNO6
Mol. Mass.469.914
SMILESCC(C)OC(=O)C1=C(C)N(Cc2ccccc2)C(C(O)=O)=C(C1c1ccccc1Cl)C(O)=O |c:6,21|
Structure
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