| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-1 |
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| Ligand | BDBM50133889 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_46875 |
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| Ki | 3170±n/a nM |
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| Citation |  Ullman, BR; Aja, T; Deckwerth, TL; Diaz, JL; Herrmann, J; Kalish, VJ; Karanewsky, DS; Meduna, SP; Nalley, K; Robinson, ED; Roggo, SP; Sayers, RO; Schmitz, A; Ternansky, RJ; Tomaselli, KJ; Wu, JC Structure-activity relationships within a series of caspase inhibitors: effect of leaving group modifications. Bioorg Med Chem Lett13:3623-6 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-1 |
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| Name: | Caspase-1 |
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| Synonyms: | CASP1_MOUSE | Casp1 | Il1bc |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45636.44 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_651546 |
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| Residue: | 402 |
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| Sequence: | MADKILRAKRKQFINSVSIGTINGLLDELLEKRVLNQEEMDKIKLANITAMDKARDLCDH
VSKKGPQASQIFITYICNEDCYLAGILELQSAPSAETFVATEDSKGGHPSSSETKEEQNK
EDGTFPGLTGTLKFCPLEKAQKLWKENPSEIYPIMNTTTRTRLALIICNTEFQHLSPRVG
AQVDLREMKLLLEDLGYTVKVKENLTALEMVKEVKEFAACPEHKTSDSTFLVFMSHGIQE
GICGTTYSNEVSDILKVDTIFQMMNTLKCPSLKDKPKVIIIQACRGEKQGVVLLKDSVRD
SEEDFLTDAIFEDDGIKKAHIEKDFIAFCSSTPDNVSWRHPVRGSLFIESLIKHMKEYAW
SCDLEDIFRKVRFSFEQPEFRLQMPTADRVTLTKRFYLFPGH
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| BDBM50133889 |
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| n/a |
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| Name | BDBM50133889 |
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| Synonyms: | (S)-3-{(S)-3-Methyl-2-[2-(naphthalen-1-yloxy)-acetylamino]-butyrylamino}-5-(naphthalen-2-yloxy)-4-oxo-pentanoic acid | CHEMBL116661 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H32N2O7 |
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| Mol. Mass. | 556.6057 |
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| SMILES | CC(C)[C@H](NC(=O)COc1cccc2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)COc1ccc2ccccc2c1 |
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| Structure | 
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