Reaction Details |
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Target | Capsid scaffolding protein |
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Ligand | BDBM50133954 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_158964 (CHEMBL769610) |
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Ki | 79±n/a nM |
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Citation | Borthwick, AD; Davies, DE; Ertl, PF; Exall, AM; Haley, TM; Hart, GJ; Jackson, DL; Parry, NR; Patikis, A; Trivedi, N; Weingarten, GG; Woolven, JM Design and synthesis of pyrrolidine-5,5'-trans-lactams (5-oxo-hexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 4. Antiviral activity and plasma stability. J Med Chem46:4428-49 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Capsid scaffolding protein |
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Name: | Capsid scaffolding protein |
Synonyms: | APNG | Assemblin | Assembly protein | Capsid protein P40 | Human cytomegalovirus protease (HCMV Pr) | Human herpes virus 5 capsid protein P40 | Protease precursor | SCAF_HCMVA | UL80 | pPR |
Type: | PROTEIN |
Mol. Mass.: | 73854.16 |
Organism: | Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) |
Description: | ChEMBL_158958 |
Residue: | 708 |
Sequence: | MTMDEQQSQAVAPVYVGGFLARYDQSPDEAELLLPRDVVEHWLHAQGQGQPSLSVALPLN
INHDDTAVVGHVAAMQSVRDGLFCLGCVTSPRFLEIVRRASEKSELVSRGPVSPLQPDKV
VEFLSGSYAGLSLSSRRCDDVEAATSLSGSETTPFKHVALCSVGRRRGTLAVYGRDPEWV
TQRFPDLTAADRDGLRAQWQRCGSTAVDASGDPFRSDSYGLLGNSVDALYIRERLPKLRY
DKQLVGVTERESYVKASVSPEAACDIKAASAERSGDSRSQAATPAAGARVPSSSPSPPVE
PPSPVQPPALPASPSVLPAESPPSLSPSEPAEAASMSHPLSAAVPAATAPPGATVAGASP
AVSSLAWPHDGVYLPKDAFFSLLGASRSAVPVMYPGAVAAPPSASPAPLPLPSYPASYGA
PVVGYDQLAARHFADYVDPHYPGWGRRYEPAPSLHPSYPVPPPPSPAYYRRRDSPGGMDE
PPSGWERYDGGHRGQSQKQHRHGGSGGHNKRRKETAAASSSSSDEDLSFPGEAEHGRARK
RLKSHVNSDGGSGGHAGSNQQQQQRYDELRDAIHELKRDLFAARQSSTLLSAALPSAASS
SPTTTTVCTPTGELTSGGGETPTALLSGGAKVAERAQAGVVNASCRLATASGSEAATAGP
STAGSSSCPASVVLAAAAAQAAAASQSPPKDMVDLNRRIFVAALNKLE
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BDBM50133954 |
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n/a |
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Name | BDBM50133954 |
Synonyms: | (3S,3aR,6aS)-1-Cyclopropanecarbonyl-3-methyl-4-[(S)-1-(4-propoxy-benzoyl)-pyrrolidine-2-carbonyl]-hexahydro-pyrrolo[3,2-b]pyrrol-2-one | CHEMBL138211 |
Type | Small organic molecule |
Emp. Form. | C26H33N3O5 |
Mol. Mass. | 467.5573 |
SMILES | CCCOc1ccc(cc1)C(=O)N1CCC[C@H]1C(=O)N1CC[C@H]2[C@H]1[C@H](C)C(=O)N2C(=O)C1CC1 |
Structure |
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