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TargetCapsid scaffolding protein
LigandBDBM50133977
Substrate/Competitorn/a
Meas. Tech.ChEMBL_158964 (CHEMBL769610)
Ki 38±n/a nM
Citation Borthwick, ADDavies, DEErtl, PFExall, AMHaley, TMHart, GJJackson, DLParry, NRPatikis, ATrivedi, NWeingarten, GGWoolven, JM Design and synthesis of pyrrolidine-5,5'-trans-lactams (5-oxo-hexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 4. Antiviral activity and plasma stability. J Med Chem46:4428-49 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Capsid scaffolding protein
Name:Capsid scaffolding protein
Synonyms:APNG | Assemblin | Assembly protein | Capsid protein P40 | Human cytomegalovirus protease (HCMV Pr) | Human herpes virus 5 capsid protein P40 | Protease precursor | SCAF_HCMVA | UL80 | pPR
Type:PROTEIN
Mol. Mass.:73854.16
Organism:Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Description:ChEMBL_158958
Residue:708
Sequence:
MTMDEQQSQAVAPVYVGGFLARYDQSPDEAELLLPRDVVEHWLHAQGQGQPSLSVALPLN
INHDDTAVVGHVAAMQSVRDGLFCLGCVTSPRFLEIVRRASEKSELVSRGPVSPLQPDKV
VEFLSGSYAGLSLSSRRCDDVEAATSLSGSETTPFKHVALCSVGRRRGTLAVYGRDPEWV
TQRFPDLTAADRDGLRAQWQRCGSTAVDASGDPFRSDSYGLLGNSVDALYIRERLPKLRY
DKQLVGVTERESYVKASVSPEAACDIKAASAERSGDSRSQAATPAAGARVPSSSPSPPVE
PPSPVQPPALPASPSVLPAESPPSLSPSEPAEAASMSHPLSAAVPAATAPPGATVAGASP
AVSSLAWPHDGVYLPKDAFFSLLGASRSAVPVMYPGAVAAPPSASPAPLPLPSYPASYGA
PVVGYDQLAARHFADYVDPHYPGWGRRYEPAPSLHPSYPVPPPPSPAYYRRRDSPGGMDE
PPSGWERYDGGHRGQSQKQHRHGGSGGHNKRRKETAAASSSSSDEDLSFPGEAEHGRARK
RLKSHVNSDGGSGGHAGSNQQQQQRYDELRDAIHELKRDLFAARQSSTLLSAALPSAASS
SPTTTTVCTPTGELTSGGGETPTALLSGGAKVAERAQAGVVNASCRLATASGSEAATAGP
STAGSSSCPASVVLAAAAAQAAAASQSPPKDMVDLNRRIFVAALNKLE
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  Blast E-value cutoff:
BDBM50133977
n/a
NameBDBM50133977
Synonyms:(2S)-2-{[(3aS,6S,6aR)-4-(Cyclopropylcarbonyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl}-N-(4-chlorophenyl)pyrrolidine-1-carboxamide | (S)-2-((3aS,6S,6aR)-4-Cyclopropanecarbonyl-6-methyl-5-oxo-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl)-pyrrolidine-1-carboxylic acid (4-chloro-phenyl)-amide | CHEMBL342014
TypeSmall organic molecule
Emp. Form.C23H27ClN4O4
Mol. Mass.458.938
SMILESC[C@H]1[C@@H]2[C@H](CCN2C(=O)[C@@H]2CCCN2C(=O)Nc2ccc(Cl)cc2)N(C(=O)C2CC2)C1=O |r|
Structure
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