| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
|---|
| Ligand | BDBM50134348 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_37595 |
|---|
| IC50 | 19000±n/a nM |
|---|
| Citation |  Senior, SJ; Illarionov, PA; Gurcha, SS; Campbell, IB; Schaeffer, ML; Minnikin, DE; Besra, GS Biphenyl-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme. Bioorg Med Chem Lett13:3685-8 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
|---|
| Name: | 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
|---|
| Synonyms: | β-Ketoacyl-acyl carrier protein (ACP) synthase III (FabH) | 3-oxoacyl-[acyl-carrier-protein] synthase III | FABH_MYCTU | fabH |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 34865.07 |
|---|
| Organism: | Mycobacterium tuberculosis |
|---|
| Description: | P9WNG3 |
|---|
| Residue: | 335 |
|---|
| Sequence: | MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDEWIYTRTGIKTRRFAADDES
AASMATEACRRALSNAGLSAADIDGVIVTTNTHFLQTPPAAPMVAASLGAKGILGFDLSA
GCAGFGYALGAAADMIRGGGAATMLVVGTEKLSPTIDMYDRGNCFIFADGAAAVVVGETP
FQGIGPTVAGSDGEQADAIRQDIDWITFAQNPSGPRPFVRLEGPAVFRWAAFKMGDVGRR
AMDAAGVRPDQIDVFVPHQANSRINELLVKNLQLRPDAVVANDIEHTGNTSAASIPLAMA
ELLTTGAAKPGDLALLIGYGAGLSYAAQVVRMPKG
|
|
|
|---|
| BDBM50134348 |
|---|
| n/a |
|---|
| Name | BDBM50134348 |
|---|
| Synonyms: | 4-Hydroxy-5-(4'-hydroxymethyl-biphenyl-4-ylmethyl)-3,5-dimethyl-5H-thiophen-2-one | CHEMBL122848 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H20O3S |
|---|
| Mol. Mass. | 340.436 |
|---|
| SMILES | CC1C(=O)SC(C)(Cc2ccc(cc2)-c2ccc(CO)cc2)C1=O |
|---|
| Structure | 
|
|---|
Search and Browse
