| Reaction Details |
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 | Report a problem with these data |
| Target | 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
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| Ligand | BDBM50134359 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_37595 |
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| IC50 | 155000±n/a nM |
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| Citation |  Senior, SJ; Illarionov, PA; Gurcha, SS; Campbell, IB; Schaeffer, ML; Minnikin, DE; Besra, GS Biphenyl-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme. Bioorg Med Chem Lett13:3685-8 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
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| Name: | 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
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| Synonyms: | β-Ketoacyl-acyl carrier protein (ACP) synthase III (FabH) | 3-oxoacyl-[acyl-carrier-protein] synthase III | FABH_MYCTU | fabH |
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| Type: | Enzyme |
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| Mol. Mass.: | 34865.07 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | P9WNG3 |
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| Residue: | 335 |
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| Sequence: | MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDEWIYTRTGIKTRRFAADDES
AASMATEACRRALSNAGLSAADIDGVIVTTNTHFLQTPPAAPMVAASLGAKGILGFDLSA
GCAGFGYALGAAADMIRGGGAATMLVVGTEKLSPTIDMYDRGNCFIFADGAAAVVVGETP
FQGIGPTVAGSDGEQADAIRQDIDWITFAQNPSGPRPFVRLEGPAVFRWAAFKMGDVGRR
AMDAAGVRPDQIDVFVPHQANSRINELLVKNLQLRPDAVVANDIEHTGNTSAASIPLAMA
ELLTTGAAKPGDLALLIGYGAGLSYAAQVVRMPKG
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| BDBM50134359 |
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| n/a |
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| Name | BDBM50134359 |
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| Synonyms: | 3,5-dimethyl-4-hydroxy-5-(4-methoxybenzyl)-5H-thiophen-2-one | 4-Hydroxy-5-(4-methoxy-benzyl)-3,5-dimethyl-5H-thiophen-2-one | CHEMBL333467 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H16O3S |
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| Mol. Mass. | 264.34 |
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| SMILES | COc1ccc(CC2(C)SC(=O)C(C)C2=O)cc1 |
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| Structure | 
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