Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50135144 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_54777 (CHEMBL884432) |
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IC50 | 196±n/a nM |
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Citation | Gangjee, A; Adair, OO; Queener, SF Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents. J Med Chem46:5074-82 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | Bacterial dihydrofolate reductase | DYR_ECOLI | Dihydrofolate Reductase (DHFR) | Tetrahydrofolate dehydrogenase | folA | tmrA |
Type: | Enzyme |
Mol. Mass.: | 17991.61 |
Organism: | Escherichia coli |
Description: | E. coli DHFR was expressed in BL21, and purified to homogeneity. |
Residue: | 159 |
Sequence: | MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI
ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
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BDBM50135144 |
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n/a |
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Name | BDBM50135144 |
Synonyms: | 6-{[Methyl-(3,4,5-trichloro-phenyl)-amino]-methyl}-pyrido[2,3-d]pyrimidine-2,4-diamine | CHEMBL149099 |
Type | Small organic molecule |
Emp. Form. | C15H13Cl3N6 |
Mol. Mass. | 383.663 |
SMILES | CN(Cc1cnc2nc(N)nc(N)c2c1)c1cc(Cl)c(Cl)c(Cl)c1 |
Structure |
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