Reaction Details |
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Target | Tyrosine-protein kinase Lck |
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Ligand | BDBM13218 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_221335 (CHEMBL841397) |
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IC50 | 28000±n/a nM |
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Citation | Wityak, J; Das, J; Moquin, RV; Shen, Z; Lin, J; Chen, P; Doweyko, AM; Pitt, S; Pang, S; Shen, DR; Fang, Q; de Fex, HF; Schieven, GL; Kanner, SB; Barrish, JC Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck). Bioorg Med Chem Lett13:4007-10 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase Lck |
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Name: | Tyrosine-protein kinase Lck |
Synonyms: | 2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase |
Type: | n/a |
Mol. Mass.: | 57987.83 |
Organism: | Homo sapiens (Human) |
Description: | P06239 |
Residue: | 509 |
Sequence: | MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
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BDBM13218 |
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n/a |
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Name | BDBM13218 |
Synonyms: | 2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide | BMS-354825 tert-Butoxycarbamate Analog 5b | CHEMBL334333 | tert-butyl N-{5-[(2-chloro-6-methylphenyl)carbamoyl]-4-methyl-1,3-thiazol-2-yl}carbamate |
Type | Small organic molecule |
Emp. Form. | C17H20ClN3O3S |
Mol. Mass. | 381.877 |
SMILES | Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cccc1Cl |
Structure |
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