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TargetProto-oncogene tyrosine-protein kinase LCK
LigandBDBM50135396
Substrate/Competitorn/a
Meas. Tech.ChEBML_221476
IC50>50000±n/a nM
Citation Wityak, JDas, JMoquin, RVShen, ZLin, JChen, PDoweyko, AMPitt, SPang, SShen, DRFang, Qde Fex, HFSchieven, GLKanner, SBBarrish, JC Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck). Bioorg Med Chem Lett13:4007-10 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Proto-oncogene tyrosine-protein kinase LCK
Name:Proto-oncogene tyrosine-protein kinase LCK
Synonyms:LCK_MOUSE | LSK | Lck | Lsk-t | Lymphocyte cell-specific protein-tyrosine kinase | Proto-oncogene tyrosine-protein kinase LCK | Tyrosine-protein kinase LCK | p56-LCK
Type:PROTEIN
Mol. Mass.:57927.84
Organism:Mus musculus
Description:ChEMBL_806408
Residue:509
Sequence:
MGCVCSSNPEDDWMENIDVCENCHYPIVPLDSKISLPIRNGSEVRDPLVTYEGSLPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHDLVRHYTNASDGLCTKLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGMAFIEEQNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKER
PEDRPTFDYLRSVLDDFFTATEGQYQPQP
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  Blast E-value cutoff:
BDBM50135396
n/a
NameBDBM50135396
Synonyms:CHEMBL336544 | [5-(2,4-Dichloro-phenylcarbamoyl)-4-methyl-thiazol-2-yl]-carbamic acid tert-butyl ester
TypeSmall organic molecule
Emp. Form.C16H17Cl2N3O3S
Mol. Mass.402.295
SMILESCc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1ccc(Cl)cc1Cl
Structure
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