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TargetTyrosine-protein kinase LCK
LigandBDBM13240
Substrate/Competitorn/a
Meas. Tech.ChEBML_221476
IC50 170±n/a nM
Citation Wityak JDas JMoquin RVShen ZLin JChen PDoweyko AMPitt SPang SShen DRFang Qde Fex HFSchieven GLKanner SBBarrish JC Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck). Bioorg Med Chem Lett 13:4007-10 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase LCK
Name:Tyrosine-protein kinase LCK
Synonyms:LSK | Lymphocyte cell-specific protein-tyrosine kinase | Proto-oncogene tyrosine-protein kinase LCK | p56-LCK
Type:PROTEIN
Mol. Mass.:57927.84
Organism:Mus musculus
Description:ChEMBL_806408
Residue:509
Sequence:
MGCVCSSNPEDDWMENIDVCENCHYPIVPLDSKISLPIRNGSEVRDPLVTYEGSLPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHDLVRHYTNASDGLCTKLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGMAFIEEQNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKER
PEDRPTFDYLRSVLDDFFTATEGQYQPQP
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  Blast E-value cutoff:
BDBM13240
n/a
NameBDBM13240
Synonyms:2-[[(Methylamino)-carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-1,3-thiazole-5-carboxamide | 4-methyl-2-[(methylcarbamoyl)amino]-N-(2,4,6-trimethylphenyl)-1,3-thiazole-5-carboxamide | BMS-354825 2-Amino-4-methyl-thiazole Analog 8a | CHEMBL338159
TypeSmall organic molecule
Emp. Form.C16H20N4O2S
Mol. Mass.332.421
SMILESCNC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cc(C)cc1C
Structure
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