| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Proto-oncogene tyrosine-protein kinase LCK |
|---|
| Ligand | BDBM13217 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_221476 (CHEMBL842063) |
|---|
| IC50 | 3000±n/a nM |
|---|
| Citation |  Wityak, J; Das, J; Moquin, RV; Shen, Z; Lin, J; Chen, P; Doweyko, AM; Pitt, S; Pang, S; Shen, DR; Fang, Q; de Fex, HF; Schieven, GL; Kanner, SB; Barrish, JC Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck). Bioorg Med Chem Lett13:4007-10 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Proto-oncogene tyrosine-protein kinase LCK |
|---|
| Name: | Proto-oncogene tyrosine-protein kinase LCK |
|---|
| Synonyms: | LCK_MOUSE | LSK | Lck | Lsk-t | Lymphocyte cell-specific protein-tyrosine kinase | Proto-oncogene tyrosine-protein kinase LCK | Tyrosine-protein kinase LCK | p56-LCK |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 57927.84 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_806408 |
|---|
| Residue: | 509 |
|---|
| Sequence: | MGCVCSSNPEDDWMENIDVCENCHYPIVPLDSKISLPIRNGSEVRDPLVTYEGSLPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHDLVRHYTNASDGLCTKLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGMAFIEEQNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKER
PEDRPTFDYLRSVLDDFFTATEGQYQPQP
|
|
|
|---|
| BDBM13217 |
|---|
| n/a |
|---|
| Name | BDBM13217 |
|---|
| Synonyms: | 2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2,4,6-trimethylphenyl)-1,3-thiazole-5-carboxamide | BMS-354825 tert-Butoxycarbamate Analog 5a | CHEMBL66109 | tert-butyl N-{4-methyl-5-[(2,4,6-trimethylphenyl)carbamoyl]-1,3-thiazol-2-yl}carbamate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H25N3O3S |
|---|
| Mol. Mass. | 375.485 |
|---|
| SMILES | Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cc(C)cc1C |
|---|
| Structure | 
|
|---|
Search and Browse
