| Reaction Details |
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 | Report a problem with these data |
| Target | Proto-oncogene tyrosine-protein kinase LCK |
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| Ligand | BDBM13215 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_221476 (CHEMBL842063) |
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| IC50 | 6600±n/a nM |
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| Citation |  Wityak, J; Das, J; Moquin, RV; Shen, Z; Lin, J; Chen, P; Doweyko, AM; Pitt, S; Pang, S; Shen, DR; Fang, Q; de Fex, HF; Schieven, GL; Kanner, SB; Barrish, JC Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck). Bioorg Med Chem Lett13:4007-10 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Proto-oncogene tyrosine-protein kinase LCK |
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| Name: | Proto-oncogene tyrosine-protein kinase LCK |
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| Synonyms: | LCK_MOUSE | LSK | Lck | Lsk-t | Lymphocyte cell-specific protein-tyrosine kinase | Proto-oncogene tyrosine-protein kinase LCK | Tyrosine-protein kinase LCK | p56-LCK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57927.84 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_806408 |
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| Residue: | 509 |
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| Sequence: | MGCVCSSNPEDDWMENIDVCENCHYPIVPLDSKISLPIRNGSEVRDPLVTYEGSLPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHDLVRHYTNASDGLCTKLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGMAFIEEQNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKER
PEDRPTFDYLRSVLDDFFTATEGQYQPQP
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| BDBM13215 |
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| n/a |
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| Name | BDBM13215 |
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| Synonyms: | 2-Aminothiazole 1 | 2-amino-4-methyl-N-(2,4,6-trimethylphenyl)-1,3-thiazole-5-carboxamide | CHEMBL307976 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H17N3OS |
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| Mol. Mass. | 275.369 |
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| SMILES | Cc1nc(N)sc1C(=O)Nc1c(C)cc(C)cc1C |
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| Structure | 
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