Reaction Details |
| Report a problem with these data |
Target | Retinoic acid receptor RXR-gamma |
---|
Ligand | BDBM50135460 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_197090 |
---|
Ki | 5.6±n/a nM |
---|
Citation | Michellys, PY; Boehm, MF; Chen, JH; Grese, TA; Karanewsky, DS; Leibowitz, MD; Liu, S; Mais, DA; Mapes, CM; Reifel-Miller, A; Ogilvie, KM; Rungta, D; Thompson, AW; Tyhonas, JS; Yumibe, N; Ardecky, RJ Design and synthesis of novel RXR-selective modulators with improved pharmacological profile. Bioorg Med Chem Lett13:4071-5 (2003) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Retinoic acid receptor RXR-gamma |
---|
Name: | Retinoic acid receptor RXR-gamma |
Synonyms: | NR2B3 | Nuclear receptor subfamily 2 group B member 3 | RXRG | RXRG_HUMAN | Retinoic acid receptor RXR-gamma | Retinoid X receptor gamma | Retinoid X receptor gamma/retinoic acid receptor alpha |
Type: | PROTEIN |
Mol. Mass.: | 50878.26 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_197216 |
Residue: | 463 |
Sequence: | MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVG
TPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPG
IGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKD
CLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERIL
EAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVI
LLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKD
MQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLL
LRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT
|
|
|
BDBM50135460 |
---|
n/a |
---|
Name | BDBM50135460 |
Synonyms: | (2E,4E,6Z)-7-[4-(2,2-Difluoro-ethoxy)-4'-fluoro-5-isopropyl-biphenyl-3-yl]-3-methyl-octa-2,4,6-trienoic acid | CHEMBL133915 |
Type | Small organic molecule |
Emp. Form. | C26H27F3O3 |
Mol. Mass. | 444.486 |
SMILES | CC(C)c1cc(cc(\C(C)=C/C=C/C(/C)=C/C(O)=O)c1OCC(F)F)-c1ccc(F)cc1 |
Structure |
|